The Buffalo Bills (9-2) will try to remain one game back of Kansas City atop the AFC standings when they host the San Francisco 49ers (5-6) on Sunday Night Football. Buffalo entered the week one game back of the Chiefs after picking up a head-to-head victory two weeks ago. San Francisco is in desperate need of a win after losing its last two games and falling below the .500 mark this season. Quarterback Brock Purdy (shoulder) missed last week’s game, but he was a full practice participant on Friday and is expected to play on Sunday.
Purdy has a passing yards over/under of 224.5 in the Bills vs. 49ers NFL props, and he is +150 (risk $100 to win $150) to throw at least two touchdowns. Purdy’s over/under for total passing completions is 20.5. Should you fade Purdy with your 49ers vs. Bills prop bets? Before betting any NFL props for Sunday Night Football or entering NFL predictions on sites like PrizePicks, you need to see the Bills vs. 49ers NFL prop predictions powered by SportsLine’s AI PickBot.
Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each player prop. The AI predictions are determined by statistically learning from each player’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score.
Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. SportsLine’s AI PickBot has nailed 2,092 4.5- and 5-star prop picks since the start of last season. Anybody who followed those picks at their best sports betting app and betting sites was way up.
For Bills vs. 49ers NFL betting on Sunday Night Football, the AI PickBot has evaluated the NFL player prop odds and provided 49ers vs. Bills prop picks for every available prop market. You can only see the AI player prop predictions for Buffalo vs. San Francisco here.
Top NFL player prop bets for Bills vs. 49ers
After analyzing 49ers vs. Bills props and examining the dozens of NFL player prop markets, the AI PickBot says Bills quarterback Josh Allen goes Over 222.5 passing yards (-117 on Caesars). Allen will have to contend with some bad weather on Sunday night, but he has surpassed 230 passing yards in five straight games. He completed 27 of 40 passes for 262 yards and a touchdown against Kansas City two weeks ago, and he is used to playing in this type of weather.
Allen has engineered a six-game winning streak following back-to-back losses earlier in the season, and Buffalo had an extra week to prepare for San Francisco’s defense. The 28-year-old has only faced San Francisco one time in his career, completing 32 of 40 passes for 375 yards and four touchdowns in 2020. The AI PickBot thinks Allen is in line for another big performance on Sunday night, projecting 272 passing yards for the MVP favorite to earn a 4.5-star prop rating. See more NFL props here.
How to make NFL player prop bets for Buffalo vs. San Francisco
In addition, the AI PickBot says another star sails past his total and has eight other NFL props rated four stars or better. You need to see the AI PickBot’s analysis before making any 49ers vs. Bills prop bets for Sunday Night Football.
Which Bills vs. 49ers prop bets should you target for Sunday Night Football? Visit SportsLine now to see the top 49ers vs. Bills props, all from the SportsLine AI PickBot that has nailed 2,092 top-rated picks since the start of last season.
